Pages: (47-51 )
Abstract
This present study assessed the association of serum uric acid (UA) and insulin resistance (IR) among obese and non-obese undergraduate students of a private Nigerian University. A descriptive cross-sectional study was conducted involving 120 undergraduates. Anthropometric measurements and biochemical analysis of fasting plasma glucose (FPG), UA and insulin were done using standard procedures. Insulin resistance was determined using the homeostasis model assessment (HOMA- IR). Participants with HOMA- IR ≥ 2 and body mass index (BMI) ≥30 kg/m2 were classified as having Insulin resistance and obesity respectively. IR prevalence was 38.3% among participants. The median serum insulin levels (13.5 interquartile range (IQR) 10.5, 34.9 vs 6.2 IQR 4.5, 9.2) and HOMA-IR (3.0 IQR2.5, 6.3, vs 1.2 IQR 0.9, 2.0) was elevated among obese participants (p<0.001). Insulin was positively correlated with UA in obese participants (p = 0.001). For every unit of increase in UA, the likelihood of IR is increased by 38% after controlling for age, gender and obesity. Serum UA was associated with IR among obese undergraduate students of a private Nigerian University.
Keywords: Insulin resistance, Obese, Uric acid, HOMA-IR, Nigeria,