Pages: (51-60 )
Abstract
Some naphthalene derivatives possess anti-inflammatory activity. This study evaluated the effects of different doses of 2,3-dimethyl naphthalene on two inflammatory models. Thirty male albino rats were assigned into six groups of five rats each. Group I: normal, group II: untreated control, group III: treated with 10 mg/kg b.w diclofenac, groups IV-VI treated with 5, 10, and 15 mg/kg b.w. 2,3-dimethyl naphthalene, respectively. Carrageenan-induced paw edema and cotton pellets-induced granuloma were used to evaluate the anti-inflammatory activity of 2,3-dimethyl naphthalene. GraphPad Prism® was used to analyze data. Data were expressed as mean ± standard error of the mean at a significance level of p < 0.05. The study revealed that 5, 10, and 15 mg/kg b.w. 2,3-dimethyl naphthalene suppressed paw edema by 55.82%, 21.49%, and 14.38% respectively, while 10 mg/kg b.w. diclofenac sodium suppressed paw edema by 81.50%. Furthermore, 5, 10 and 15 mg/kg b.w 2,3-dimethyl naphthalene significantly (p < 0.05) inhibited cotton pellets-induced granuloma by 11.48%, 38.52% and 39.69%, respectively, while 10 mg/kg b.w. diclofenac sodium inhibited cotton pellets-induced granuloma by 59.28%. Thus findings from this study showed that 2,3-dimethyl naphthalene could exhibit anti-inflammatory actions and its mechanism might be through interference with phase 2 of inflammatory stressors
Keywords: 2,3-dimethyl naphthalene, carrageenan, cotton-pellets granuloma, paw edema inflammation,