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Abstract
This study was designed to determine the effects of magnesium-aluminum preparation on the antibacterial activity of Cotrimoxazole, a combination of Trimethoprim (TMP) and Sulfamethoxazole (SMX) in the ratio 1:5, on clinical isolates. Different concentrations of TMP and SMX were combined and tested against the clinical isolates using the agar diffusion method. Each of the combined concentrations of TMP:SMX was then combined with different concentrations of magnesium-aluminum hydroxide and tested against clinical isolates of Proteus morganella, Citrobacter freundii, Klebsiella edwardsii, Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus and zones of inhibition were measured where present. The effects of magnesium-aluminum preparations on the antibacterial activities of cotrimoxazole were observed to be antagonistic in nature. One-way ANOVA indicated that the interaction between cotrimoxazole and magnesium-aluminum preparation is significant (p<0.05). The study indicated that magnesium-aluminum preparation significantly reduced the effects of the antibacterial activity of cotrimoxazole on the clinical isolates. However, resistant colonies were not observed within the zones of inhibition.
Keywords: Antibiotic, Cotrimoxazole and Magnesium - Aluminum ions,